Oral BPC-157 (“Body Protection Compound”) is derived from a protective protein in human gastric juice, and is a synthetic peptide studied for healing, recovery, and inflammation control. Since it originates in stomach tissue, it’s unusually stable when taken orally. Rupa Health

Gut/GI effects (strongest research base)

• Demonstrated oral stability in gastric juice and efficacy even at microgram or nanogram doses Rupa Health
• May support repair of ulcers and mitigate damage from NSAIDs like aspirin and diclofenac Rupa Health
• Shows potential for supporting management of chronic GI conditions such as IBD, including ulcerative colitis Rupa Health
• Direct contact with the mucosal lining supports leaky gut, barrier function restoration, and general digestive optimization Bhrcenter

Systemic/beyond-gut effects (weaker, more theoretical)

• Research suggests orally administered BPC-157 can achieve systemic distribution, supporting healing in joints, muscles, and connective tissue via growth factor modulation and angiogenesis Bhrcenter
• Preliminary research suggests brain-supportive benefits, promoting nerve tissue integrity and potentially aiding balance of neurotransmitters like serotonin and dopamine Pure Prescriptions
• May aid nerve regeneration and reduce neuronal damage, supporting recovery after stroke or spinal cord injury (again, animal data) Rupa Health
• Some research points to liver-supportive effects tied to detoxification and metabolism Pure Prescriptions